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Atovaquone and proguanil price in US $/tonne 2016 The price of proguanil (propranolol) rose to new all-time highs in the US 2016, driven largely by the demand for its primary application in advanced heart failure treatment. The price of drug (its in US $/tonne 2016) was more than double what it was in 2013, when the most expensive medication on list of approved drugs and had a market cap of US $2 billion. The US Food and Drug Administration (FDA) announced a new policy in March 2016 that allows generic manufacturers to produce cheaper versions of the drug, which means that there is opportunity for proguanil competitors to enter a market expected grow at CAGR of 5 per cent in 2017 and 5.5 per cent in 2018, depending on sales volumes. With the new generic regulations in place, Pfizer can likely price its proguanil even lower in the future, and a way that would lower prices for patients, as long it doesn't go to generic manufacturers first. In this study, we use a meta-analysis approach to compare Pfizer's total sales and patient costs (including indirect such as lost productivity) for its two leading treatments heart failure, Xarelto® and Plavix®, in the US market between 2007 and 2016. Our main results were that there has been a significant downward trend in the total sales Drugstore sales tax of these two products, with a significant decrease in sales of the generic versions Propranolol and Plavix. Pfizer's total sales of Xarelto® decreased by $6.86 billion (6.6 per cent) from 2007 to 2016 (Fig. 1), while its total Buy online tretinoin cream sales of Plavix®, on the other hand, decreased by $1.9 billion (4.7 per cent), from 2007 to 2016. Total sales of the brand-name Xarelto and Plavix in the US rose by 1.1 per cent and 0.9 cent, respectively, from 2007 to 2016, with the generic versions of both drugs experiencing a significant increase atovaquone generic price in demand. Figure 1: Pfizer's total sales of Plavix (including the generic version) in United States from 2007 to 2016 The total patient cost of Xarelto® (the generic version the drug) decreased over 60 per cent from 2007 to 2016, 2.5 per cent of total sales to 1.5 per cent (Fig. 2). However, we estimate that the generic version of drug will have significantly reduced total costs, with costs for the generic version decreasing by 53 per cent from 2007 to 2016. Figure 2: Total patient costs of Xarelto® (including the generic version) in United States for 2007 to 2016 As of December 1 2016, the median patient cost of Plavix® has increased by 4.6 per cent, from US $1,100 to $1,300 per month. Figure 3: Median cost of Plavix® in the United States December 2016 Our second main finding is that the median total cost per patient increased from $15,400 to $16,300 in 2016 (Fig. 3). We estimate that the generic versions of Xarelto and Plavix have reduced total costs for patients by around 16 per cent, and that the generic versions of both drugs will have reduced total costs to patients by around 12 per cent in the next five years (not including indirect costs such as lost productivity).


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